IMproving PULmonary hypertension Screening by Echocardiography: IMPULSE

Table 4 Receiver operating characteristic analysis of the TTE PH parameters

TTE parameter	BSE Cut-off value	AUC	95% CI	P-value	Sensitivity (%)	Specificity (%)
Lower peak TRV (m/s) (N = 257)	> 2.8	0.87	0.83–0.91	P < 0.001	83	73
Upper peak TRV (m/s) (N = 257)	> 3.4	0.87	0.83–0.91	P < 0.001	60	98
End systolic eccentricity index (N = 274)	> 1.1	0.78	0.72–0.84	P < 0.001	64	83
End diastolic eccentricity index (N = 267)	> 1.1	0.75	0.69–0.81	P < 0.001	46	93
RV/LV basal diameter ratio (N = 249)	> 1.0	0.74	0.67–0.81	P < 0.001	47	91
RVOT acceleration time (ms) (N = 290)	< 105	0.78	0.71–0.84	P < 0.001	84	54
MPA diameter (mm) (N = 125)	> 25	0.71	0.60–0.81	P < 0.01	40	91
PRV_BD (m/s) (N = 92)	> 2.2	0.82	0.73– 0.91	P < 0.001	61	94
Right atrial area (cm²) (N = 310)	> 18	0.73	0.66–0.79	P < 0.001	57	81
RVFWLS (-%) (N = 155)	< − 23	0.78	0.71–0.85	P < 0.001	81	58
RVFAC (%) (male) (N = 33)	< 30	0.72	0.61–0.83	P < 0.001	65	69
RVFAC (%) (female) (N = 48)	< 35	0.72	0.61–0.83	P < 0.001	64	70
Indexed right atrial area (cm²/m²) (N = 268)	> 11	0.74	0.67–0.81	P < 0.001	42	89
RV TDI E’ (N = 228)	< 8.5	0.67	0.60–0.74	P < 0.001	55	74
RV TDI E’/A’ ratio (N = 219)	< 0.65	0.66	0.58–0.73	P < 0.001	86	28
RV TDI IVRT (N = 164)	> 73	0.72	0.62–0.82	P < 0.001	81	62

TTE Transthoracic echocardiography, AUC area under curve, CI confidence interval, BSE British Society of Echocardiography, TRV tricuspid regurgitant velocity, RV right ventricle, LV left ventricle, PRV_BD pulmonary regurgitant velocity at begging of diastole, MPA main pulmonary artery, RVOT right ventricular outflow tract, MSN mid-systolic notching, IVC inferior vena cava, RVFWLS right ventricular free wall longitudinal strain, TDI tissue doppler imaging, IVRT isovolumetric relaxation time, RVFAC right ventricular fractional area of change, RVOT right ventricular outflow tract, PRV_BD pulmonary regurgitation velocity beginning of diastole, RVFWLS right ventricular free wall longitudinal strain, RVFAC right ventricular fractional area of change

ISSN: 2055-0464