Fig. 6

Cerebral vascular map and velocity distribution for a porcine hydrocephalus model at the baseline ICP. a A heatmap of all the trajectories containing at least 4 exposures visualizing the micro- and macro-vascular distributions in a coronal plane. The blue star marks the location of pulsed-wave Doppler ultrasound measurement. b The corresponding time-averaged velocity distribution. c Several sub-regions are labelled for statistical analysis of perfusion, including the micro-vessels in the thalamus (#1), several parts of the cortex (#2, #3, and #4), as well as a macro blood vessel (#5). A few regions are magnified to provide a closer view of the current regions of interest. Sample velocity profiles across two different blood vessels are also provided in c. d, e Relationships between the ICP and the Cerebral Microcirculation (CMC) parameter of the cortical regions #2–4. The CMC parameter is calculated by summing the time-averaged velocity (in mm/s) in each pixel of the area occupied by micro-vessels, and dividing the result by the total area of these regions. The pulse pressure (PP) is systolic blood pressure minus diastolic blood pressure