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Does stress echocardiography still have a role in the rapid access chest pain clinic post NICE CG95?

Abstract

Introduction: The 2016 NICE clinical guideline 95 (CG95) demoted functional imaging to a second-line test following computed tomography coronary angiography (CTCA). Many cardiac CT services in the UK require substantial investment and growth to implement this. Chest pain services like ours are likely to continue to use stress testing for the foreseeable future. We share service evaluation data from our department to show that a negative stress echocardiogram can continue to be used for chest pain assessment.

Methods: 1815 patients were referred to rapid access chest pain clinic (RACPC) between June 2013 and March 2015. 802 patients had stress echocardiography as the initial investigation. 446 patients had normal resting left ventricular (LV) systolic function and a negative stress echocardiogram. At least 24 months after discharge, a survey was carried out to detect major adverse cardiovascular events (MACE) (cardiac death, myocardial infarction, admission to hospital for heart failure or angina, coronary artery disease at angiography, revascularisation by angioplasty or coronary artery bypass grafting) within 2 years.

Results: Overall, 351 patients were successfully followed up. The mean Diamond-Forrester (D-F) score and QRISK2 suggested a high pre-test probability (PTP) of coronary artery disease (CAD). There were nine deaths (eight non-cardiac deaths and one cardiac death). MACE occurred in four patients with a mean time of 17.5 months (11.6–23.7 months). The annual event rate was 0.6%.

Conclusion: A negative stress echocardiogram can reliably reassure patients and clinicians even in high PTP populations with suspected stable angina. It can continue to be used to assess stable chest pain post CG95.

References

  1. Heijenbrok-Kal MH, Fleischmann KE & Hunink MGM. Stress echocardiography, stress single-photon-emission computed tomography and electron beam computed tomography for the assessment of coronary artery disease: a meta-analysis of diagnostic performance. American Heart Journal 2007 154 415–423. (https://doi.org/10.1016/j.ahj.2007.04.061)

    Article  Google Scholar 

  2. de Jong MC, Genders TSS, van Geuns RJ, Moelker A & Hunink MGM. Diagnostic performance of stress myocardial perfusion imaging for coronary artery disease: a systematic review and meta-analysis. European Radiology 2012 22 1881–1895. (https://doi.org/10.1007/s00330-012-2434-1)

    Article  Google Scholar 

  3. Marwick TH, Case C, Vasey C, Allen S, Short L & Thomas JD. Prediction of mortality by exercise echocardiography A strategy for combination with the duke treadmill score. Circulation 2001 103 2566–2571. (https://doi.org/10.1161/01.CIR.103.21.2566)

    Article  CAS  Google Scholar 

  4. Marwick TH, Mehta R, Arheart K & Lauer MS. Use of exercise echocardiography for prognostic evaluation of patients With known or suspected coronary artery disease. Journal of the American College of Cardiology 1997 30 83–90. (https://doi.org/10.1016/S0735-1097(97)00148-4)

    Article  CAS  Google Scholar 

  5. Fleischmann KE, Hunink MGM, Kuntz KM & Douglas PS. Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance. JAMA 1998 280 913–920. (https://doi.org/10.1001/jama.280.10.913)

    Article  CAS  Google Scholar 

  6. Metz LD, Beattie M, Hom R, Redberg RF, Grady D & Fleischmann KE. The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography A meta-analysis. Journal of the American College of Cardiology 2007 49 227–237. (https://doi.org/10.1016/j.jacc.2006.08.048)

    Article  Google Scholar 

  7. Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, Bugiardini R, Crea F, Cuisset T, Di Mario C, et al. ESC guidelines on the management of stable coronary artery disease. European Heart Journal 2013 34 2949–3003. (https://doi.org/10.1093/eurheartj/eht296)

    Article  Google Scholar 

  8. Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, Douglas PS, Foody JM, Gerber TC, Hinderliter AL, et al. ACCF/AHA/ACP/AATS/PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease writing committee members. Journal of the American College of Cardiology 2012 60 e44–e164. (https://doi.org/10.1016/j.jacc.2012.07.013)

    Article  Google Scholar 

  9. British Society of Cardiovascular Imaging & British Society of Cardiac Computed Tomography. Projected requirement for CTCA following updated NICE GG95 guidelines. Glasgow, UK: BSCI/BSCCT, 2016. (available at: http://www.bsci.org.uk/standards-guidelines/nice-cg95-update-2016?id=178)

    Google Scholar 

  10. Fyyaz S, Papachristidis A & Byrne J. Opinions on the expanding role of CTCA in patients with stable chest pain and beyond: a UK survey. British Journal of Cardiology 2018 25 107–109. (https://doi.org/10.5837/bjc.2018.019)

    Google Scholar 

  11. Diamond GA & Forrester JS. Analysis of probability as an aid in the clinical diagnosis of coronary-artery disease. New England Journal of Medicine 1979 300 1350–1358. (https://doi.org/10.1056/NEJM197906143002402)

    Article  CAS  Google Scholar 

  12. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A & Brindle P. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ 2008 336 1475–1482. (https://doi.org/10.1136/bmj.39609.449676.25)

    Article  Google Scholar 

  13. Becher H, Chambers J, Fox K, Jones R, Leech GJ, Masani N, Monaghan M, More R, Nihoyannopoulos P, Rimington H, et al. BSE procedure guidelines for the clinical application of stress echocardiography, recommendations for performance and interpretation of stress echocardiography: a report of the British Society of Echocardiography Policy Committee. Heart 2004 90 (Supplement 6) vi23–vi30. (https://doi.org/10.1136/hrt.2004.047985)

    PubMed  PubMed Central  Google Scholar 

  14. British Society of Cardiovascular Imaging & The Royal College of Radiologists. Coronary CT provision 2018. Glasgow, UK: BSCI/RCR, 2018. (available at: http://www.bsci.org.uk/standards-guidelines/coronary-cta-provision)

    Google Scholar 

  15. Senior R, Monaghan M, Becher H, Mayet J & Nihoyannopoulos P & British Society of Echocardiography. Stress echocardiography for the diagnosis and risk stratification of patients with suspected or known coronary artery disease: a critical appraisal. Supported by the British Society of Echocardiography. Heart 2005 91 427–436. (https://doi.org/10.1136/hrt.2004.044396)

    Article  CAS  Google Scholar 

  16. Sicari R, Pasanisi E, Venneri L, Landi P, Cortigiani L, Picano E, Echo Persantine International Cooperative (EPIC) Study Group & Echo Dobutamine International Cooperative (EDIC) Study Group. Stress echo results predict mortality: a large-scale multicenter prospective international study. Journal of the American College of Cardiology 2003 41 589–595. (https://doi.org/10.1016/S0735-1097(02)02863-2)

    Article  Google Scholar 

  17. Metz LD, Beattie M, Hom R, Redberg RF, Grady D & Fleischmann KE. The prognostic value of normal exercise myocardial perfusion imaging and exercise echocardiography A meta-analysis. Journal of the American College of Cardiology 2007 49 227–237. (https://doi.org/10.1016/j.jacc.2006.08.048)

    Article  Google Scholar 

  18. Chung G, Krishnamani R & Senior R. Prognostic value of normal stress echocardiogram in patients with suspected coronary artery disease–a British general hospital experience. International Journal of Cardiology 2004 94 181–186. (https://doi.org/10.1016/j.ijcard.2003.03.020)

    Article  Google Scholar 

  19. Mccully RB, Roger VL, Mahoney DW, Karon BL, Oh JK, Miller FA, Seward JB & Pellikka PA. Outcome after normal exercise echocardiography and predictors of subsequent cardiac events: follow-up of 1325 patients. Journal of the American College of Cardiology 1998 31 144–149. (https://doi.org/10.1016/S0735-1097(97)00427-0)

    Article  CAS  Google Scholar 

  20. Papachristidis A, Roper D, Cassar Demarco D, Tsironis I, Papitsas M, Byrne J, Alfakih K & Monaghan MJ. The prognostic role of stress echocardiography in a contemporary population and the clinical significance of limited apical ischaemia. Echo Research and Practice 2016 3 105–113. (https://doi.org/10.1530/ERP-16-0033)

    Article  Google Scholar 

  21. National Institute for Health and Care Excellence. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin (update). NICE guideline CG95: methods, evidence and recommendations (final version). London, UK: NICE, 2016. (available at: https://www.nice.org.uk/guidance/cg95/evidence/full-guideline-245282221)

    Google Scholar 

  22. Douglas PS, Hoffmann U, Lee KL, Mark DB, Al-Khalidi HR, Anstrom K, Dolor RJ, Kosinski A, Krucoff MW, Mudrick DW, et al. PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial. American Heart Journal 2014 167 796.e1–803.e1. (https://doi.org/10.1016/j.ahj.2014.03.003)

    Article  Google Scholar 

  23. SCOT-HEART Investigators. CT coronary angiography in patients with suspected angina due to coronary heart disease (SCOT-Heart): an open-label, parallel-group, multicentre trial. Lancet 2015 385 2383–2391. (https://doi.org/10.1016/S0140-6736(15)60291-4)

    Article  Google Scholar 

  24. Gianrossi R, Detrano R, Mulvihill D, Lehmann K, Dubach P, Colombo A, McArthur D & Froelicher V. Exercise-induced ST depression in the diagnosis of coronary artery disease A meta-analysis. Circulation 1989 80 87–98. (https://doi.org/10.1161/01.CIR.80.1.87)

    Article  CAS  Google Scholar 

  25. National Institute for Health and Care Excellence. HeartFlow FFRCT for estimating fractional flow reserve from coronary CT angiography. Medical technologies guidance [MTG32]. London, UK: NICE, 2017. (available at: https://www.nice.org.uk/guidance/mtg32/chapter/1-Recommendations)

    Google Scholar 

  26. Budoff MJ. The 2016 National Institute for Health and Care Excellence guidelines for chest pain: better outcomes with cardiac CT. Heart 2018 104 186–187. (https://doi.org/10.1136/heartjnl-2017-311776)

    Article  Google Scholar 

  27. Upton MT, Rerych SK, Newman GE, Port S, Cobb FR & Jones RH. Detecting abnormalities in left ventricular function during exercise before angina and ST-segment depression. Circulation 1980 62 341–349. (https://doi.org/10.1161/01.CIR.62.2.341)

    Article  CAS  Google Scholar 

  28. Bhattacharyya S, Chehab O, Khattar R, Lloyd G & Senior R. Stress echocardiography in clinical practice: a United Kingdom National Health Service Survey on behalf of the British Society of Echocardiography. European Heart Journal: Cardiovascular Imaging 2014 15 158–163. (https://doi.org/10.1093/ehjci/jet082)

    PubMed  Google Scholar 

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Correspondence to Victoria Pettemerides MBBS BSc MRCP.

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Pettemerides, V., Turner, T., Steele, C. et al. Does stress echocardiography still have a role in the rapid access chest pain clinic post NICE CG95?. Echo Res Pract 6, 17–23 (2019). https://doi.org/10.1530/ERP-18-0082

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