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British Society for Echocardiography and British Cardio-Oncology Society guideline for transthoracic echocardiographic assessment of adult cancer patients receiving anthracyclines and/or trastuzumab

Guidelines and Recommendations

Echo Research & Practice volume 8, pages G1–G18 (2021)Cite this article

Abstract

The subspecialty of cardio-oncology aims to reduce cardiovascular morbidity and mortality in patients with cancer or following cancer treatment. Cancer therapy can lead to a variety of cardiovascular complications, including left ventricular systolic dysfunction, pericardial disease, and valvular heart disease. Echocardiography is a key diagnostic imaging tool in the diagnosis and surveillance for many of these complications. The baseline assessment and subsequent surveillance of patients undergoing treatment with anthracyclines and/or human epidermal growth factor (EGF) receptor (HER) 2-positive targeted treatment (e.g. trastuzumab and pertuzumab) form a significant proportion of cardio-oncology patients undergoing echocardiography. This guideline from the British Society of Echocardiography and British Cardio-Oncology Society outlines a protocol for baseline and surveillance echocardiography of patients undergoing treatment with anthracyclines and/or trastuzumab. The methodology for acquisition of images and the advantages and disadvantages of techniques are discussed. Echocardiographic definitions for considering cancer therapeutics-related cardiac dysfunction are also presented.

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Authors and Affiliations

  1. Cardio-Oncology Service, Liverpool Heart and Chest NHS Foundation Trust, Liverpool, UK

    Rebecca Dobson MBChB (Hons) MD

  2. Cardio-Oncology Service, Barts Heart Centre, Barts Health NHS Trust, London, UK

    Arjun K. Ghosh MBBS MSc PhD & Charlotte Manisty MBBS MA PhD

  3. Cardio-Oncology Service, Hatter Cardiovascular Research Institute, University College London and University College London Hospitals NHS Foundation Trust, London, UK

    Arjun K. Ghosh MBBS MSc PhD

  4. Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Bonnie Ky MD MSCE

  5. Baker Heart and Diabetes Institute, Melbourne, Australia

    Tom Marwick MBBS PhD MPH

  6. University Hospital South Manchester NHS Foundation Trust, Manchester, UK

    Martin Stout PhD & Keith Pearce BSc

  7. East Suffolk and North Essex NHS Foundation Trust, Colchester, UK

    Allan Harkness MB ChB MSc

  8. University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK

    Rick Steeds MA MD

  9. North West Anglia Foundation Trust, UK

    Shaun Robinson MA MD

  10. Liverpool John Moores University, Liverpool, UK

    David Oxborough PhD

  11. University Hospitals of Leicester NHS Trust, Leicester, UK

    David Adlam BA BM BCh DPhil

  12. Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK

    Susannah Stanway MB ChB MSc MD

  13. Imperial College Healthcare NHS Trust, London, UK

    Bushra Rana MBBS

  14. The Shrewsbury and Telford Hospital NHS Trust, Shrewsbury, UK

    Thomas Ingram MB ChB PhD

  15. West Suffolk NHS Foundation Trust, Bury St Edmunds, UK

    Liam Ring MBBS

  16. Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, UK

    Stuart Rosen MA MD & Alexander R. Lyon MD PhD

  17. The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, UK

    Chris Plummer BSc PhD BM BCh

  18. Belfast Health and Social Care Trust, Belfast, UK

    Mark Harbinson MB BCh MMedSci MD

  19. Royal Liverpool and Broadgreen University Hospitals NHS Trust, Liverpool, UK

    Vishal Sharma MD

  20. Department of Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK

    Daniel X. Augustine MD

  21. Department for Health, University of Bath, Bath, UK

    Daniel X. Augustine MD

Authors
  1. Rebecca Dobson MBChB (Hons) MD
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  2. Arjun K. Ghosh MBBS MSc PhD
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  17. Charlotte Manisty MBBS MA PhD
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  18. Mark Harbinson MB BCh MMedSci MD
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  19. Vishal Sharma MD
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  20. Keith Pearce BSc
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  21. Alexander R. Lyon MD PhD
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  22. Daniel X. Augustine MD
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Corresponding author

Correspondence to Rebecca Dobson MBChB (Hons) MD.

Additional information

(R Dobson and A K Ghosh contributed equally to this work)

Anju Nohria, MD, served as the Editor-in-Chief for this paper. Juan Carlos Plana Gomez, MD, served as the Guest Associate Editor for this paper. The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug

Administration guidelines, including patient consent where appropriate.

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Dobson, R., Ghosh, A.K., Ky, B. et al. British Society for Echocardiography and British Cardio-Oncology Society guideline for transthoracic echocardiographic assessment of adult cancer patients receiving anthracyclines and/or trastuzumab. Echo Res Pract 8, G1–G18 (2021). https://doi.org/10.1530/ERP-21-0001

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  • DOI: https://doi.org/10.1530/ERP-21-0001

Keywords

Echo Research & Practice

ISSN: 2055-0464

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